An Indian uprising on March 22, 1622, abruptly halted plans to develop Henrico and its university. The Indians regarded the colony's rapid development as a threat.
On Good Friday morning, Indians attacked settlements throughout the colony. Houses were burned. Men, women, and children were murdered. Henricus was almost completely demolished. Most survivors retreated to Jamestown or other nearby settlements. The city called Henrico was abandoned. The site of Henrico's first settlement was part of a large land grant made to William Farrar, Sr., and came to be known as Farrar's Island.
In the years following the Indian uprising of 1622, the colonists engaged in regular attacks against the Indians, pushing them farther and farther westward.